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Patients should be counseled that weight loss plateaus are normal and do not indicate medication failure
Because these systems also regulate sleep, changes in sleep patterns can occur
Supplementary Figures Acknowledgements We would like to thank the Scientific Technology Platforms (STPs) at The Francis Crick Institute, particularly High Throughput Screening for their collaboration to develop the arrayed CRISPR-Cas9 screen, and the Biological Research Facility for breeding and maintenance of mouse lines
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