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Additional common gastrointestinal effects during early treatment include: Diarrhea (affecting 18-24% of patients) usually begins within the early weeks of treatment Constipation (occurring in 16-17% of patients) can develop as gastric motility decreases Vomiting (reported by 8-10% of patients) typically accompanies more severe nausea episodes Abdominal pain or discomfort (affecting 6-10% of patients) often described as cramping or bloating Decreased appetite (experienced by 6-10% of patients) usually noticeable within the first few days Dyspepsia (indigestion) and eructation (belching) additional common digestive symptoms Beyond gastrointestinal symptoms, some patients experience injection site reactions including redness, itching, or mild swelling at the administration site