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MiR-122 was the first miRNA identified as tissue-specific, and it is the most abundant in liver involved in lipid metabolic reprogramming 83
"But microdosing has not been well studied in clinical trials, and most of the data is anecdotal." She said that when someone asks her about microdosing a GLP-1, she advises that, since it's off-label (meaning not approved by the FDA), carefully monitoring their blood sugar, weight, and symptoms is essential
GLP-1 medications, originally developed to lower blood sugars, have also proven to be effective for weight loss (1)
However, relevant clinical evidence in humans remains limited
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