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used a hydro-alcoholic extract of Moringa to treat experimental colitis in mice, and observed downregulation of a group of secreted inflammatory factors and an increase of both colon lengths and the expression of glutathione-S-Transferase Pi 1 (GSTP1), which is a detoxifying enzyme mediated by NFE2-Related Factor 2 (NRF2) ( Chronic inflammation is also associated with metabolic disorders, such as non-alcoholic steatohepatitis (NASH) caused by hepatic lipid accumulation, and high-fat diet induced glucose intolerance
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These data support the conclusion that GLP-1R expression in these inflammatory conditions (AP/CP), can also occur in non-stellate cells (acinar cells, islet cells and inflammatory cells)
doi:10.3389/fnut.2024.1406618
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