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Motivation While semaglutides economic success as a GLP-1R agonist sets a benchmark for the market, it will not be the best GLP-1R agonist in glycemic control and weight management, and there is still need for continued innovation in the progression of peptide-based therapies for metabolic disorders, as exemplified in the history of insulin of continued design and development of analogues with enhanced pharmacological profiles [1, 3234]
While human clinical trials remain limited, decades of animal research and growing community experience suggest a favorable risk profile when used responsibly
Routine Placement
REDEFINE 2 (overweight/obesity with T2D) showed a 15.7% mean weight reduction and 73.5% achieving HbA1c 6.5%
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