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Under oxidative or nitrosative stress, GSH covalently binds to exposed cysteine thiols on enzymes, protecting them from irreversible oxidation and modulating their activity
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Despite being mechanistically different, pyroptosis, ferroptosis, apoptosis, necroptosis act synergistically via shared signaling nodes in DKD, with mitochondrial ROS (mtROS) and serving as a pivotal common mediator (112, 176, 207)
Vitamin B12 shots are the most common way to prevent or treat a deficiency
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