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First, 20 mg of chitosan (medium molecular weight, 75% deacetylated, Sigma-Aldrich, USA) was dissolved in 10 mL of 1% (v/v) acetic acid under magnetic stirring (500 rpm, 25 C, 2 h) to yield a 0.2% (w/v) solution, and the pH was adjusted to 4.8 with 1 M NaOH

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First, we excluded case and non-case reports with gastrointestinal events (all PTs belonged to gastrointestinal disorders in the system organ class) in the dataset

16 Administration of GSH resulted in a significantly higher urine volume (approximately 20%) on the first and second postoperative days, with a trend to lower blood urea nitrogen and plasma creatinine concentrations in the GSH group that did not reach statistical significance