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ETCO , end-tidal carbon dioxide
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Proposed Mechanisms (Preclinical) Incretin & Islet Biology GIP receptor activation: Studied for potentiation of glucose-dependent insulin secretion and effects on -cell function in metabolic models
According to 3 multicenter, randomized, double-blind, placebo-controlled obesity trials (BMI 30, or BMI 27 with at least 1 comorbidity of hypertension, dyslipidemia, or type 2 diabetes) conducted to evaluate the effect of CONTRAVE in conjunction with reduced caloric intake and increased physical activity, the average percentage of weight loss in patients at 56 weeks ranged from 3.7% to 8.1% with CONTRAVE, compared to 1.3% to 4.9% with placebo
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