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Acute attacks frequently precipitate SIADH, and large volumes of hypotonic fluids such as D10W can accelerate dilutional hyponatremia and precipitate fluid overload
Ottaway, T.D
The 12.5 mg dose is not part of the standard brand-name escalation (Mounjaro and Zepbound jump directly from 10 mg to 15 mg in 2.5 mg single-dose pens)
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