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Akkermansia muciniphila a gut bacterium that lives on your intestinal mucus layer has shown promising metabolic effects in a small human pilot study and may stimulate GLP-1 through microbe-to-hormone pathways in preclinical work
From there, KDIGO supports what is often described as a four-pillar framework in T2D CKD: RAAS inhibition as the base, followed by SGLT2 inhibitors, non-steroidal MRAs for T2D with albuminuric CKD, and GLP-1 receptor agonists for T2D with CKD layered to reduce kidney and cardiovascular risk
Two consistent compound sources
This pattern can help maintain a stable blood sugar level and reduce the risk of gastrointestinal side effects
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