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The hyperglycemia-related increased proximal tubular sodium reabsorption results in lower sodium levels at the level of the macula densa increasing GFR via inhibiting TGF, further augmenting the amount of filtered and reabsorbed sodium with increased ATP demands
In vitro , dendritic cells and fibroblasts expressing Slc7a11 contribute to extracellular redox regulation through glutathione synthesis and maintain cysteine supply to Slc7a11 -deficient cells, such as lymphocytes
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