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Broad gene-mapping work led by Pickart and colleagues reported modulation of thousands of genes, with roughly a third of human gene patterns shifting toward expression states associated with younger or healthier tissue

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Here, we demonstrate that dihexa binds with high affinity to hepatocyte growth factor (HGF) and both dihexa and its parent compound Norleucine 1-AngIV (Nle1- AngIV) induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF- dependent cell scattering

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