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For instance, it has been known for quite some time that these two diuretics may directly impair insulin secretion from islets in vitro and deteriorate glucose tolerance in mice (Sandstrom, 1988
A., Heath, L., Perkovic, A., Vaduganathan, M., Badve, S
High doses of estradiol also significantly decrease the amount of insulin receptors and the insulin receptor substrate 1 (IRS-1) levels in muscle and adipose tissue in vitro (174)
Conditions such as cardiovascular problems, hormone-sensitive cancers, severe diabetes complications, and liver issues can increase risks when these medications are combined
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