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179,180 Red cells contain L-hexonate dehydrogenase, an enzyme that has the capacity to reduce aldoses such as glucose, galactose, or glyceraldehyde to their corresponding polyol (i.e., glucose to sorbitol, galactose to dulcitol, and glyceraldehyde to glycerol)
Conversely, [U- 13 C]glucose tracing showed GGCT overexpression enhanced Glc-derived carbon flux into the TCA cycle (increased m + 2 labeling of succinate, fumarate, malate), which was reversed by the E98A mutant (Fig
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Foster, M
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