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However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo
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Given their non-invasive nature, accessibility, and cost-effectiveness of sublingual formulations, they may represent a promising approach for long-term B12 management, particularly in patients with impaired absorption or in resource-limited settings
This includes: Pernicious anemia Crohns disease or celiac disease Gastric surgery or gastrointestinal disorders For mild deficiency, starting with 1,000 mcg of Vitamin B12 weekly is common
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