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It has dual receptor action, which may lead to greater appetite suppression in some patients
However, clinicians should remain vigilant for signs of excessive metabolic suppression or thyroid dysfunction, particularly in patients with pre-existing thyroid conditions or those experiencing symptoms beyond cold intolerance, such as severe fatigue, hair loss, or cognitive changes that might suggest thyroid hormone imbalance requiring investigation
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Retatrutide acts on three hormone receptors GLP-1, GIP, and glucagon whereas Ozempic acts on GLP-1 alone
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