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In this review, we explore the current understanding of lipedema through clinical, tissue, and cellular lenses, and examine suspected pathological mechanisms, including hormonal influences (such as estrogen), adipocyte hypertrophy and hyperplasia, increased extracellular matrix (ECM) fibrosis, and specialized immune cell involvement, including M2 macrophage infiltration
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Experimental research has suggested its potential to slow alterations in reproductive and immune systems and improve life spans in mice and rats
May aid exercise recovery
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