Instead of forcing a response, it appears to remove bottlenecks and enhance processes that are already trying to happen
An elegant data analysis of the STEP-2 protocol shows the temporal dynamic of this effect, where the incidence of nausea grew from ~5% at the beginning of the dose escalation period (week 1
Statements Ethics statement Animal experiments were conducted according to the Guide for the Care and Use of Laboratory Animals (National Research Council, National Academy Press, Washington, DC, 2011) and all of the institutional regulations and guidelines for animal experimentation after pertinent review and approval by the Institutional Animal Care and Use Committee of Nagasaki University (approval number 1407281164-4)
Peng F, Wang JH, Fan WJ, Meng YT, Li MM, Li TT, et al