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Cytosolic Ca 2+ entering the mitochondrial matrix through the mitochondrial Ca 2+ uniporter (MCU) stimulates OXPHOS by activating pyruvate dehydrogenase phosphatase, which in turn, increases the activity of pyruvate dehydrogenase complex [21]
You would not judge semaglutide based on results at 0.25mg
To indirectly evaluate the impact of treatment duration, we conducted a sensitivity analysis restricted to patients who received a second tirzepatide prescription between six months and one year after the index date
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