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The polymerase chain reaction (PCR) products were subjected to agarose gel electrophoresis and purified using an Omega DNA purification kit (Omega Inc., Norcross, GA, United States)
Eli Lilly published the results of its ATTAIN-1b trial for obesity in September 2025 7 , which compared orforglipron to placebo in more than 3,100 adults without diabetes, with a BMI of 30+ or 27-30 with an obesity-related complication including hypertension, dyslipidaemia, cardiovascular disease or obstructive sleep apnoea and a history of at least one patient-reported unsuccessful dietary effort to lose body weight, who have tried unsuccessfully to lose weight with diet alone
The most commonly reported include nausea, constipation, diarrhea, vomiting, decreased appetite, and, occasionally, fatigue
When patients ask about longterm risks, be transparent about what is known and unknown
