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Therefore, in peri- and post-menopausal patients, rapid or substantial weight loss while on semaglutide may plausibly unmask or intensify GSM symptoms via endocrine and tissue-level changesalthough the specific contribution of semaglutide vs weight loss per se is not established
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In a meta-analysis including seven CVOTs and approximately 56 thousand participants, the use of GLP1RAs in patients with type 2 diabetes reduced the risk of total stroke by 16% (HR = 0.84
These are firm boundaries, not judgment calls
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