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Biological and metabolic factors (largely theoretical for retatrutide): Hormonal profile: It is hypothesised that individuals with differing baseline levels of GLP-1, GIP, and glucagon may respond differently to receptor stimulation, but this has not been formally demonstrated for retatrutide and should be regarded as speculative

Blood was sampled from the subjects one week before and after the presentation of CJC-1295 peptide (and placebo) to monitor the levels of growth hormone pulsatility