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This is primarily mediated by aquaporin water channels (for example, AQP4) and inwardly rectifying K + channels such as Kir4.1, which are often colocalized at astrocytic endfeet adjacent to blood vessels

Patients should be reassured that gastrointestinal side effects often improve over time as the body adjusts to the medication, particularly if dose escalation is gradual as recommended in the prescribing information

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