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Description

GLP-1, an incretin hormone, responds to this increase in glucose by stimulating insulin release from the pancreas and signaling the brain to enhance feelings of fullness

These help evaluate new therapies for glucose control and insulin sensitivity

In 2008, they developed trastuzumab emtansine (Kadcyla, T-DM1), an ADC consisting of a trastuzumab antibody bound to the drug emtansine, which disrupts the microtubules that form part of a cells internal skeleton