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SCFAs exert anti-inflammatory properties through the suppression of pro-inflammatory mediators, including cytokines (TNF-, IL-6, and IL-1) as well as chemokines such as C-C motif ligand 2 (CCL2), C-C motif ligand 8 (CCL8), C-X-C motif ligand 5 (CXCL5), C-X-C motif ligand 8 (CXCL8), and C-X-C motif ligand 10 (CXCL10)

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A few small studies have suggested that allulose may modestly increase postprandial GLP-1 levels when consumed with carbohydrates, potentially through mechanisms involving intestinal sensing of nutrients

Treatment was associated with fibrosis improvement by at least one stage with no worsening in non-alcoholic fatty liver disease (NAFLD) activity score in 25% of resmetirom recipients versus just under 15% in the placebo group