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While this persistence rate is a marked improvement over the 10% observed for obesity-indicated GLP-1s, it still leaves 76% of potential demand unrealized
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Retatrutide is an investigational triple-agonist (GLP-1, GIP, and glucagon) with a half-life of roughly 6 days (Coskun et al., Cell Metabolism, 2022)
However, investigations of the AP and vagal nerve neurons revealed that the appetite-lowering effects of the drug (liraglutide) were independent of the GLP-1R in these cells
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