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Insulin resistance may occur in some patients with diabetes, requiring higher insulin doses for adequate glycemic control
In most cases, this happens as the skin adjusts to the product
Also, NSAIDs can adversely influence blood pressure regulation by interfering with renal prostaglandin synthesis, especially when used concurrently with angiotensin-converting enzyme (ACE) inhibitors, diuretics, and -blockers (Whelton 1999
This mechanism extends beyond simple angiogenesis to sophisticated vascular reprogramming
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