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Several drugs that modulate the activity of these nuclear receptors have been investigated as treatments for NASH in patients (Figure 2)

Conclusion: Given the highly potent pan-genotypic antiviral activity of BEM and RZR, the high resistance barrier of BEM, the complementary mechanisms of action of BEM and RZR, the clinically demonstrated safety and efficacy of each agent when administered individually, and the lack of drug-drug interaction( DDI) between BEM and RZR, combination treatment with these two agents for HCV infections is highly attractive and is currently being evaluated in a Phase 2 clinical trial

We did not modify the question about the number of tiers a firms cost-sharing structure has, but in cases in which the highest tier covered exclusively specialty drugs we reported it separately

The tradeoff between tolerability and rate of weight loss is a personal decision, but staying on a tolerable dose long-term is almost always better than cycling on and off the maximum dose