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Many patients eventually reduce their dose, switch to maintenance-level dosing, or transition off the medication entirely
in HFpEF, the prevalence of obesity reaches up to 80%
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In addition, GLP-1RAs can effectively upregulate the expression of myogenic regulatory factors MyoD and MyoG, while inhibiting the transcription of key ubiquitin-ligases MAFbx and MuRF1 in muscle atrophy
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