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Not about your weight, but about what that weight actually means for how long you'll stay healthy, strong, and functional as you get older

Those with digestive issues, like Crohns disease or celiac disease, that impair nutrient absorption

In a 2001 editorial published in the European Journal of Anesthesiology , Pollard & Pomfrett describe DSIP as incredibly safe because (a) no dose had ever killed an animal subject in clinical research and (b) no significant side effects apart from transient headache, nausea, and vertigo in humans have been reported.4 But the U.S

REDEFINE 1, in adults with overweight or obesity without diabetes, reported 22.7% mean weight loss for the combination at 68 weeks on the on-treatment analysis, with 60% of combination participants reaching at least 20% loss and 23% reaching at least 30% (Aronne et al., 2025)