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Semaglutide is the proven GLP-1 agonist that established the modern obesity pharmacotherapy era
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Interestingly, there is cross-talk between sulfonylurea and incretin signaling involving the activation of the exchange protein activated by cyclic-AMP 2A (Epac2A)-Ras-like small GTPase 1 (RAP1) pathway, which may augment insulin secretion from pancreatic -cells upon exposure to the combination of both drugs [45,46]
Ako se prvi put susreete sa ovom terapijom, preporuujemo da proitate na vodi ta su GLP-1 lekovi za mravljenje i kako deluju , gde je detaljno objanjen njihov mehanizam delovanja
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