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[81] This complex is much more lipophilic than the water-soluble vitamin B 12 , so is able to pass through cellular membranes with greater ease
The compounds effects on NAD+ metabolism may have implications for muscle biology given the importance of NAD+-dependent enzymes in muscle function
In fact, several studies in 2000s have documented that lifelong IM injection for replacement is still a common and usual practice
In laboratory studies, inhibiting NNMT has been investigated for effects on cellular NAD+ levels and adipocyte (fat-cell) metabolism
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