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Relative mRNA expression of Gclm (p = 0.0026), Hmox1 , Nqo1 , and Slc7a11 (d) and representative immunohistochemistry of indicated proteins (e) in Gclc WT and Gclc KO tumors (n = 6 representative from 3 independent experiments)

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Berk M, Dean OM, Cotton SM, et al

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If the liver is sluggish or overwhelmed by toxins, it may produce too much or too little SHBG, or it may fail to clear out "spent" hormones effectively

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