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To assess whether circulating GLP-1 has access to the OB, we administered LUXendin 645, a fluorescent GLP-1R antagonist based on Ex9 19 , intraperitoneally (IP)
however, the dual agonist elicited a greater reduction in body weight in both species relative to the GLP-1R agonist alone
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The sulfhydryl group of GSH binds NAPQI, which is subsequently excreted in the urine as mercapturic acid or cysteine conjugates [13, 20]
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