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This is an important nuance: GLP-1 therapy, including orforglipron, is primarily a metabolic intervention
Drugs in context
While their glycemic, weight-lowering, and cardiovascular benefits are well established through randomized trials and meta-analyses, concerns remain regarding their safety and tolerability across diverse populations and clinical settings
Why Constipation Occurs with GLP-1 Treatment Constipation during GLP-1 treatment results from several interconnected physiological mechanisms
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