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The Application of Bovine Brain Microvessel Endothelial-Cell Monolayers Grown onto Polycarbonate Membranes in Vitro to Estimate the Potential Permeability of Solutes Through the BloodBrain Barrier

10.1016/j.addr.2016.03.001 128 NottetH

Doses Per Vial Vial duration varies by dose and escalation phase: 5mg vial: At 0.5mg/week = 10 weeks (starting phase) At 1mg/week = 5 weeks At 2mg/week = 2.5 weeks At 4mg/week = 1.25 weeks 10mg vial: At 2mg/week = 5 weeks At 4mg/week = 2.5 weeks At 8mg/week = 1.25 weeks At 12mg/week = less than 1 week For the escalation phase (0.5mg to 4mg), a single 5mg vial typically covers the first several weeks