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2021 NEJM) at 2.4 mg weekly for 68 weeks produced 14.9% weight loss

Contraindications and safety considerationspersonal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or pancreatitisremain constant regardless of injection timing

Clinical trials have demonstrated semaglutide effectiveness for weight management, with an average of 15 percent body weight lost after 52 weeks of treatment in obese and overweight patients who had no history of diabetes, hypertension or cardiovascular disease