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Mitochondrial dysfunction in HD includes impaired electron transport chain activity, reduced mitochondrial biogenesis, and defective mitophagy, all of which contribute to increased oxidative stress and neuronal damage [165]
For example, there is a seven times greater risk of diabetes in obese people compared to those of healthy weight, with a three-fold increase in risk for overweight people[14]
The WHO itself warned of the likelihood of global shortages
Conclusion GLP-1R agonists have revolutionized diabetes and obesity management , but their role in perioperative care remains complex
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