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Understanding the differences between Phase I and Phase II metabolism is crucial for assessing the overall metabolic fate of drugs and xenobiotics, predicting their pharmacological activities and toxicity, and optimizing drug therapy

Methotrexate Because of the potential for liver damage when taking methotrexate, people with alcoholism or impaired liver function, such as those with cirrhosis or hepatitis, should not take this drug

Toxic metal complexes can be detoxified by conversion to insoluble derivatives or by binding them in rigid molecular environments using chelating agents

Four cysteines of the membrane protein DsbB act in concert to oxidize its substrate DsbA