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The slowing of gastric emptying with GLP-1RA treatment increases the propensity for retained gastric contents, which could increase the risk of aspiration during upper gastrointestinal endoscopy or general anesthesia
The molecule is very large, making it difficult for the skin to absorb effectively from the surface
People with a history of severe GI reactions to GLP-1 agonists are the most obvious candidates
In contrast, dapagliflozin treatment improved the homoeostasis model assessment 2 estimate of insulin resistance (HOMA2-IR) compared with semaglutide treatment
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