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Description

Studies on metformin, another diabetes medication that affects B12 absorption, show deficiency rates of 5 to 30 percent with long-term use

Deutsches Register Klinischer Studien (DRKS) (2024) Inhalation safety and pharmacokinetics of the cysteine cathepsin inhibitor aloxistatin (E64d) a phase 1 trial (COALITION-I)

Patients should be treated initially with metformin because it is the only medication shown in randomized controlled trials to reduce mortality and complications