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When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in asthmatic human airway epithelial cells (HAECs), binds phosphatidylethanolamine-binding protein 1 (PEBP1), hydroperoxy-phospholipids, which drive ferroptotic cell death, are generated
(Frontiers in Pharmacology, 2022) reported pharmacokinetics and tissue distribution in rats and dogs, including a rapid plasma half-life under 30 minutes after IM or IV dosing
PMID: 33811948
They may drift back toward the same carbohydrate-rich foods that caused trouble in the first place, regain the weight and conclude that diets do not work
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