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Although there are variations in the NPs used for mRNA delivery, the effectiveness of mRNA expression remains insufficient to meet clinical requirements
Notably, BoNT/X was approximately tenfold more toxic than X(PC) in this cell line, as measured by CellTiter-Glo assay 48 h after transfection (Extended Data Fig
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
However, controlled production conditions can achieve reproducible site occupancy distributions, supporting large-scale manufacturing despite the inherent heterogeneity
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