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Claim Strength Matrix for Skin, Hair, and Healing Claims Skin aging claims are moderate when limited to topical cosmetic outcomes, wound-healing claims are context-dependent because evidence includes both human diabetic-ulcer research and animal models, and hair growth claims remain preliminary or indirect [2], [3], [6], [13]
Exercise is a cornerstone strategy for healthy aging, yet it can be challenging for older adults due to reduced tolerance and slower recovery (Marino and Calder, 2017)
2017 Cell study used 5 mg/kg intraperitoneal injection three times per week in aged mice, with treatment periods of several weeks the three-times-weekly dosing suggests the peptide maintains sufficient functional concentrations for at least 48-72 hours per dose (PMID: 28340339)
Oxygen and glucose deprivation (OGD) mimics ischemic stroke-induced hyper-permeability of HBMECs due to internalization of VE-cadherin and is dependent on activation of the RhoA/Rock pathway (Chen et al., 2+ in BECs and pericytes and was correlated with the loss of TJs, AJs, increased BBB permeability, and pericyte death (Imai et al., 2019)
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