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Cysteine residues in Keap1 act as sensors for electrophiles and oxidants, and their oxidation leads to the release and subsequent translocation of Nrf2 into the nucleus where it can bind to the ARE4 sequence in the promoter region of genes involved in antioxidant defense (Moinova and Mulcahy 1999)
ZhengPChenJZhouCZengLLiKSunLet alIdentification of sex-specific urinary biomarkers for major depressive disorder by combined application of Nmr-and GcMs-based metabonomics
This is also when lifestyle factors like activity level, sleep quality, and protein intake become even more critical to continued progress
Importantly, these studies are unable to control for key confounders of cancer risk and this dataset is inherently prone to multiple types of bias
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