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Frequent nighttime urination that disrupts sleep
Although originally developed for the treatment of metabolic diseases, GLP-1-based therapies are now recognized for their influence on the same brain systems mediating drug-seeking and reward, suggesting therapeutic potential beyond glycemic control
Little work has previously been undertaken to evaluate safety with long-term efficacy and cardio-renal benefits of such therapies
Moreover, the SELECT study showed that semaglutide significantly reduced the incidence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke (hazard ratio 0.80) ( 6 Practical issues when prescribing GLP-1RA in T1D GLP-1RA are not currently approved for treatment of T1D, but they may still be covered by insurance if prescribed to treat obesity in these patients (although insurance coverage for obesity remains limited)
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