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Research-use-only status All four compounds remain unapproved for human therapeutic use in the United States

Evidence-based treatments for depression, including cognitive behavioural therapy (CBT), antidepressants, and other psychological interventions, remain the first-line approaches recommended by NICE for managing depressive disorders

Because it escapes binding to these inhibitory proteins, IGF-1 LR3 remains free in experimental environments to interact continuously with the IGF-1 receptor, resulting in an extended biological half-life and vastly increased potency compared to standard IGF-1

Hanu et al., 2016) (Figure 1)