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Positive compounds (pantothenate, pantethine, vitamin E, omega 3, L-carnitine or thiamine) increased PANK2 and mtACP expression levels in several PKAN cell lines with residual PANK2 levels Next, we examined the effectiveness of beneficial compounds at 5 M in three additional cell lines (P2, P3 and P4) carrying mutations with residual protein expression levels (Fig
184,185 The downstream repair machineries comprise homologous recombination repair (HRR), nonhomologous end joining (NHEJ), base excision repair (BER), nucleotide excision repair (NER), and mismatch repair (MMR)
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