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Deletions in PWS, particularly those affecting genes involved in neural development, brain function, infertility, and circadian rhythm, such as SNORD116, can result in proconvertase 1 deficiency leading to GHD, short stature, hypogonadism, hyperghrelinemia, relative hypoinsulinemia, and T2DM

Fortunately, it is rarely serious

Indeed, dulaglutide shows sex-specific treatment differences, as males reduce their intake levels more than females, and the treatment effect persists after discontinuation in males but not in females ( Although these initial studies directly manipulate GLP-1R or GLP-1, other ways to influence the GLP-1 pathway are less studied

Dose-equivalence claims require direct comparative studies measuring relevant outcomes