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In general, cancer is accompanied by chronic anemia, mediated by high concentrations of hepcidin and exacerbated by therapeutic interventions such as chemotherapy
Key takeaway Glutathione synthesis is a nutrient-dependent, stepwise process
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The buffering of antioxidant species can be accomplished by reduced glutathione (GSH), that is also required for phase II detoxification in which endogenous and exogenous toxic metabolites are conjugated to GSH for their removal [10], [11]
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